The problem
The efficacy of antidepressants prescribed to patients with major depressive disorder is around 40%, which means that 60% of treated patients do not derive therapeutic benefit.
![Opade Project – Graphic 1](https://opade-project.eu/wp-content/uploads/2023/04/Opade-Project-Graphic-1.png)
50% of MDD
cases started in adolescence. Children are considered as ‘little adults’ in the anti-depressant development while they do not have the same organism.
![Opade Project – Graphic 6](https://opade-project.eu/wp-content/uploads/2023/04/Opade-Project-Graphic-6.png)
Primary care:
Most of the patients consult their GPs who are not expert in depression: 53% of the patients are not properly diagnosed.
![Opade Project – Graphic 5](https://opade-project.eu/wp-content/uploads/2023/04/Opade-Project-Graphic-5.png)
76%
of the adult patients do not receive treatment in primary care.
![The efficacy of antidepressants prescribed to patients with major depressive disorder is around 40% The efficacy of antidepressants prescribed to patients with major depressive disorder is around 40%](https://opade-project.eu/wp-content/uploads/2023/04/The-problem-of-OPADE.png)
![Opade Project – Graphic 2](https://opade-project.eu/wp-content/uploads/2023/04/Opade-Project-Graphic-2.png)
71% of the patients have worsening sympthoms due to non individualised trewatment approach.
![Opade Project – Graphic 3](https://opade-project.eu/wp-content/uploads/2023/04/Opade-Project-Graphic-3.png)
Therapies need to be taken for 4 to 6 weeks before seeing improvement.
![Opade Project – Graphic 4](https://opade-project.eu/wp-content/uploads/2023/04/Opade-Project-Graphic-4.png)
Standard of care:
Trial error approach to find the right anti-depressant for a patient.
![OPADE Project – The problem OPADE Project - The problem](https://opade-project.eu/wp-content/uploads/2023/04/OPADE-Project-The-problem.jpg)